Mayo Clinic rendering

A rendering of the expanded Phoenix, Ariz., campus of the Mayo Clinic.

While the Mayo Clinic's $5 billion Unbound developments in downtown Rochester, Minn., is the famed medical center's larger program, it's also spending $1.9 billion to expand its Phoenix, Ariz., campus, according to postbulletin.com.

Mayo Clinic will expand its campus in Phoenix and add 1.2 million sq. ft. of space by significantly expanding an existing building and constructing a new one.

The Phoenix expansion, which was announced on March 3, 2025, is part of Mayo Clinic's "Bold. Forward. Unbound." infrastructure projects. Aside from the Rochester and Phoenix projects, an ongoing expansion is continuing at the Jacksonville, Fla., campus, according to post-bulletin.com. The Mayo Clinic Health System also recently completed projects in Mankato, Minn., and LaCrosse, Wis.

"Through this work, we are physically and digitally transforming health care and blurring the lines between inpatient and outpatient care to support category-of-one health care for our patients, a category-of-one workplace for our staff and to serve as a blueprint for the world," Gianrico Farrugia, Mayo Clinic's president and CEO, said in a news release.

An initial design and construction team of McCarthy, Gensler and Arup Group was formed, with more collaborators named in the coming months, according to the release.

"Bold. Forward. Unbound. in Arizona" will include a new procedural building as well as expansion of the existing Mayo Clinic Specialty Building. That expansion will add new technology, 11 operating rooms and 48 hospital beds across two units, as well as a "four-floor vertical and horizontal expansion." A two-story indoor promenade will connect the two buildings.

"Another prominent feature in the new design will be the development of care neighborhoods that cluster complementary clinical services for a more intuitive and connected patient experience," according to the news release.

The Arizona expansion is expected to be completed in 2031, a year after the five Unbound buildings in downtown Rochester are set for completion, according to postbulletin.com.

"‘Bold. Forward. Un-bound. in Arizona' will increase clinical space on the Phoenix campus by nearly 60 percent, allowing us to care for more patients than ever before," said Richard Gray, CEO of Mayo Clinic in Arizona. "We look forward to setting new standards for patient care and medical innovation.

"The dramatic growth in our metropolitan area, state and region has led to an escalating need for care of patients with complex medical conditions that is difficult to accommodate with our current technology and infrastructure. We continue to believe that Arizona is a great place to advance new cures, new collaborations and Mayo's distinctive model of care."

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